The 2016 Symposium of the International Academy of Legal Medicine (IALM) will discuss the present and future evolution of Bio-Medicolegal Sciences in the post-genomic framework of Personalized Medicine, in terms of Innovation, Unitariness and Evidence. The unitariness of the “Bio-Medicolegal Sciences”, historically founded on the accuracy and rigor of the methods of ascertainment and criteria of evaluation, should reestablish itself on molecular evidence, in the promotion of a Personalized Justice.